1vyx

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[[Image:1vyx.gif|left|200px]]
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{{STRUCTURE_1vyx| PDB=1vyx | SCENE= }}
{{STRUCTURE_1vyx| PDB=1vyx | SCENE= }}
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'''SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN'''
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===SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN===
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==Overview==
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RING domains are found in a large number of eukaryotic proteins. Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step in the ubiquitination process. Structurally, these domains have been characterized as binding two zinc ions in a stable cross-brace motif. The tumorigenic human gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus encodes a ubiquitin-protein ligase termed K3, which functions as an immune evasion molecule by ubiquitinating major histocompatibility complex class I. K3 possesses at its N terminus a domain related to cellular RING domains but with an altered zinc ligand arrangement. This domain was initially characterized as a plant homeodomain, a structure not previously known to function as an E3. Here, it is conclusively demonstrated that the K3 N-terminal domain is a variant member of the RING domain family and not a plant homeodomain. The domain is found to interact with the cellular ubiquitin-conjugating enzymes UbcH5A to -C and UbcH13, which dock to the equivalent surface as on classical cellular RING domains. Interaction with UbcH13 suggests a possible role for K3 in catalyzing Lys(63)-linked ubiquitination.
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(as it appears on PubMed at http://www.pubmed.gov), where 15465811 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15465811}}
==About this Structure==
==About this Structure==
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1VYX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA].
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1VYX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VYX OCA].
==Reference==
==Reference==
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[[Category: Ring domain]]
[[Category: Ring domain]]
[[Category: Zinc-binding protein]]
[[Category: Zinc-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:55:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:40:55 2008''

Revision as of 13:41, 28 July 2008

Image:1vyx.png

Template:STRUCTURE 1vyx

SOLUTION STRUCTURE OF THE KSHV K3 N-TERMINAL DOMAIN

Template:ABSTRACT PUBMED 15465811

About this Structure

1VYX is a Single protein structure of sequence from Human herpesvirus 8. Full experimental information is available from OCA.

Reference

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain., Dodd RB, Allen MD, Brown SE, Sanderson CM, Duncan LM, Lehner PJ, Bycroft M, Read RJ, J Biol Chem. 2004 Dec 17;279(51):53840-7. Epub 2004 Sep 30. PMID:15465811

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