2jm3

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{{STRUCTURE_2jm3| PDB=2jm3 | SCENE= }}
{{STRUCTURE_2jm3| PDB=2jm3 | SCENE= }}
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'''Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)'''
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===Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)===
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==Overview==
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The THAP (Thanatos-associated protein) domain is a recently discovered zinc-binding domain found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. It contains a single zinc atom ligated by cysteine and histidine residues within a Cys-X(2-4)-Cys-X(35-53)-Cys-X(2)-His consensus. We have determined the NMR solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP) and show that it adopts a fold containing a treble clef motif, bearing similarity to the zinc finger-associated domain (ZAD) from Drosophila Grauzone. The CtBP THAP domain contains a large, positively charged surface patch and we demonstrate that this domain can bind to double-stranded DNA in an electrophoretic mobility-shift assay. These data, together with existing reports, indicate that THAP domains might exhibit a functional diversity similar to that observed for classical and GATA-type zinc fingers.
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{{ABSTRACT_PUBMED_17174978}}
==About this Structure==
==About this Structure==
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2JM3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM3 OCA].
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2JM3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM3 OCA].
==Reference==
==Reference==
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[[Category: Protein]]
[[Category: Protein]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:41:00 2008''

Revision as of 13:41, 28 July 2008

Image:2jm3.png

Template:STRUCTURE 2jm3

Solution structure of the THAP domain from C. elegans C-terminal binding protein (CtBP)

Template:ABSTRACT PUBMED 17174978

About this Structure

2JM3 is a Single protein structure of sequence from Caenorhabditis elegans. Full experimental information is available from OCA.

Reference

Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP)., Liew CK, Crossley M, Mackay JP, Nicholas HR, J Mol Biol. 2007 Feb 16;366(2):382-90. Epub 2006 Nov 18. PMID:17174978

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