1p9h

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{{STRUCTURE_1p9h| PDB=1p9h | SCENE= }}
{{STRUCTURE_1p9h| PDB=1p9h | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA'''
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===CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA===
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==Overview==
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The crystal structure of the recombinant collagen-binding domain of Yersinia adhesin YadA from Yersinia enterocolitica serotype O:3 was solved at 1.55 A resolution. The trimeric structure is composed of head and neck regions, and the collagen binding head region is a novel nine-coiled left-handed parallel beta-roll. Before the beta-roll, the polypeptide loops from one monomer to the rest, and after the beta-roll the neck region does the same, making the transition from the globular head region to the narrower stalk domain. This creates an intrinsically stable 'lock nut' structure. The trimeric form of YadA is required for collagen binding, and mutagenesis of its surface residues allowed identification of a putative collagen-binding surface. Furthermore, a new structure-sequence motif for YadA beta-roll was used to identify putative YadA-head-like domains in a variety of human and plant pathogens. Such domains may therefore be a common bacterial strategy for avoiding host response.
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{{ABSTRACT_PUBMED_14765110}}
==About this Structure==
==About this Structure==
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[[Category: Collagen-binding]]
[[Category: Collagen-binding]]
[[Category: Left-handed beta-roll]]
[[Category: Left-handed beta-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:43:30 2008''

Revision as of 13:43, 28 July 2008

Image:1p9h.png

Template:STRUCTURE 1p9h

CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA

Template:ABSTRACT PUBMED 14765110

About this Structure

1P9H is a Single protein structure of sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA.

Reference

The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll., Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A, EMBO J. 2004 Feb 25;23(4):701-11. Epub 2004 Feb 5. PMID:14765110

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