2fgh

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[[Image:2fgh.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fgh| PDB=2fgh | SCENE= }}
{{STRUCTURE_2fgh| PDB=2fgh | SCENE= }}
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'''ATP bound gelsolin'''
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===ATP bound gelsolin===
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==Overview==
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Calcium activation of the actin-modifying properties of gelsolin is sensitive to ATP. Here, we show that soaking calcium-free gelsolin crystals in ATP-containing media results in ATP occupying a site that spans the two pseudosymmetrical halves of the protein. ATP binding involves numerous polar and hydrophobic contacts and is identical for the two copies of gelsolin related by non-crystallographic symmetry within the crystal. The gamma-phosphate of ATP participates in several charge-charge interactions consistent with the preference of gelsolin for ATP, as a binding partner, over ADP. In addition, disruption of the ATP-binding site through Ca2+ activation of gelsolin reveals why ATP binds more tightly to the inactive molecule, and suggests how the binding of ATP may modulate the sensitivity of gelsolin to calcium ions. Similarities between the ATP and PIP2 interactions with the C-terminal half of gelsolin are evident from their overlapping binding sites and in that both molecules bind more tightly in the absence of calcium ions. We propose a model for how PIP2 may bind to calcium-free gelsolin based on the ATP-binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 16469333 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16469333}}
==About this Structure==
==About this Structure==
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[[Category: Atp]]
[[Category: Atp]]
[[Category: Gelsolin]]
[[Category: Gelsolin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:51:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:47:26 2008''

Revision as of 13:47, 28 July 2008

Image:2fgh.png

Template:STRUCTURE 2fgh

ATP bound gelsolin

Template:ABSTRACT PUBMED 16469333

About this Structure

2FGH is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

The structure of gelsolin bound to ATP., Urosev D, Ma Q, Tan AL, Robinson RC, Burtnick LD, J Mol Biol. 2006 Mar 31;357(3):765-72. Epub 2006 Jan 25. PMID:16469333

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