This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2b3o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2b3o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2b3o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b3o| PDB=2b3o | SCENE= }}
{{STRUCTURE_2b3o| PDB=2b3o | SCENE= }}
-
'''Crystal structure of human tyrosine phosphatase SHP-1'''
+
===Crystal structure of human tyrosine phosphatase SHP-1===
-
==Overview==
+
<!--
-
SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as a negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the crystal structure of the C-terminal truncated human SHP-1 in the inactive conformation at 2.8-A resolution and refined the structure to a crystallographic R-factor of 24.0%. The three-dimensional structure shows that the ligand-free SHP-1 has an auto-inhibited conformation. Its N-SH2 domain blocks the catalytic domain and keeps the enzyme in the inactive conformation, which supports that the phosphatase activity of SHP-1 is primarily regulated by the N-SH2 domain. In addition, the C-SH2 domain of SHP-1 has a different orientation from and is more flexible than that of SHP-2, which enables us to propose an enzymatic activation mechanism in which the C-SH2 domains of SHPs could be involved in searching for phosphotyrosine activators.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12482860}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12482860 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12482860}}
==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Shp-1]]
[[Category: Shp-1]]
[[Category: Signaling]]
[[Category: Signaling]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:48:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:51:02 2008''

Revision as of 13:51, 28 July 2008

Image:2b3o.png

Template:STRUCTURE 2b3o

Crystal structure of human tyrosine phosphatase SHP-1

Template:ABSTRACT PUBMED 12482860

About this Structure

2B3O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein-tyrosine phosphatase SHP-1., Yang J, Liu L, He D, Song X, Liang X, Zhao ZJ, Zhou GW, J Biol Chem. 2003 Feb 21;278(8):6516-20. Epub 2002 Dec 13. PMID:12482860

Page seeded by OCA on Mon Jul 28 16:51:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b3o"
Personal tools