2cct

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2cct.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2cct.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2cct| PDB=2cct | SCENE= }}
{{STRUCTURE_2cct| PDB=2cct | SCENE= }}
-
'''HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE'''
+
===HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE===
-
==Overview==
+
<!--
-
Novel piperazinyl, morpholino and piperidyl derivatives of the pyrazole-based Hsp90 inhibitor CCT018159 are described. Structure-activity relationships have been elucidated by X-ray co-crystal analysis of the new compounds bound to the N-terminal domain of human Hsp90. Key features of the binding mode are essentially identical to the recently reported potent analogue VER-49009. The most potent of the new compounds has a methylsulfonylbenzyl substituent appended to the piperazine nitrogen, possesses an IC50 of less than 600 nM binding against the enzyme and demonstrates low micromolar inhibition of tumour cell proliferation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16480864}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16480864 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16480864}}
==About this Structure==
==About this Structure==
Line 44: Line 48:
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Pyrazole]]
[[Category: Pyrazole]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:49:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:54:27 2008''

Revision as of 13:54, 28 July 2008

Image:2cct.png

Template:STRUCTURE 2cct

HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE

Template:ABSTRACT PUBMED 16480864

About this Structure

2CCT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

4-Amino derivatives of the Hsp90 inhibitor CCT018159., Barril X, Beswick MC, Collier A, Drysdale MJ, Dymock BW, Fink A, Grant K, Howes R, Jordan AM, Massey A, Surgenor A, Wayne J, Workman P, Wright L, Bioorg Med Chem Lett. 2006 May 1;16(9):2543-8. Epub 2006 Feb 9. PMID:16480864

Page seeded by OCA on Mon Jul 28 16:54:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cct"
Personal tools