2d4c

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{{STRUCTURE_2d4c| PDB=2d4c | SCENE= }}
{{STRUCTURE_2d4c| PDB=2d4c | SCENE= }}
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'''Crystal structure of the endophilin BAR domain mutant'''
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===Crystal structure of the endophilin BAR domain mutant===
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==Overview==
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The crescent-shaped BAR (Bin/Amphiphysin/Rvs-homology) domain dimer is a versatile protein module that senses and generates positive membrane curvature. The BAR domain dimer of human endophilin-A1, solved at 3.1 A, has a unique structure consisting of a pair of helix-loop appendages sprouting out from the crescent. The appendage's short helices form a hydrophobic ridge, which runs across the concave surface at its center. Examining liposome binding and tubulation in vitro using purified BAR domain and its mutants indicated that the ridge penetrates into the membrane bilayer and enhances liposome tubulation. BAR domain-expressing cells exhibited marked plasma membrane tubulation in vivo. Furthermore, a swinging-arm mutant lost liposome tubulation activity yet retaining liposome binding. These data suggested that the rigid crescent dimer shape is crucial for the tubulation. We here propose that the BAR domain drives membrane curvature by coordinate action of the crescent's scaffold mechanism and the ridge's membrane insertion in addition to membrane binding via amino-terminal amphipathic helix.
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{{ABSTRACT_PUBMED_16763557}}
==About this Structure==
==About this Structure==
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[[Category: Takeda, S.]]
[[Category: Takeda, S.]]
[[Category: Bar domain]]
[[Category: Bar domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:41:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:55:29 2008''

Revision as of 13:55, 28 July 2008

Image:2d4c.png

Template:STRUCTURE 2d4c

Crystal structure of the endophilin BAR domain mutant

Template:ABSTRACT PUBMED 16763557

About this Structure

2D4C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms., Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N, EMBO J. 2006 Jun 21;25(12):2889-97. Epub 2006 Jun 8. PMID:16763557

Page seeded by OCA on Mon Jul 28 16:55:29 2008

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