2chy

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{{STRUCTURE_2chy| PDB=2chy | SCENE= }}
{{STRUCTURE_2chy| PDB=2chy | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS'''
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===THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS===
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==Overview==
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Homologies among bacterial signal transduction proteins suggest that a common mechanism mediates processes such as chemotaxis, osmoregulation, sporulation, virulence, and responses to nitrogen, phosphorous and oxygen deprivation. A common kinase-mediated phosphotransfer reaction has recently been identified in chemotaxis, nitrogen regulation, and osmoregulation. In chemotaxis, the CheA kinase passes a phosphoryl group to the cytoplasmic protein CheY, which functions as a phosphorylation-activated switch that interacts with flagellar components to regulate motility. We report here the X-ray crystal structure of the Salmonella typhimurium CheY protein. The determination of the structure was facilitated by the use of site-specific mutagenesis to engineer heavy-atom binding sites. CheY is a single-domain protein composed of a doubly wound five-stranded parallel beta-sheet. The phosphoacceptor site in CheY is probably a cluster of aspartic-acid side chains near the C-terminal edge of the beta-sheet. The pattern of sequence similarity of CheY with components of other regulatory systems can be interpreted in the light of the CheY structure and supports the view that this family of proteins have a common structural motif and active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 2645526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2645526}}
==About this Structure==
==About this Structure==
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[[Category: Stock, J B.]]
[[Category: Stock, J B.]]
[[Category: Signal transduction protein]]
[[Category: Signal transduction protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:11:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:57:54 2008''

Revision as of 13:57, 28 July 2008

Image:2chy.png

Template:STRUCTURE 2chy

THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS

Template:ABSTRACT PUBMED 2645526

About this Structure

2CHY is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis., Stock AM, Mottonen JM, Stock JB, Schutt CE, Nature. 1989 Feb 23;337(6209):745-9. PMID:2645526

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