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1o70

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{{STRUCTURE_1o70| PDB=1o70 | SCENE= }}
{{STRUCTURE_1o70| PDB=1o70 | SCENE= }}
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'''NOVEL FOLD REVEALED BY THE STRUCTURE OF A FAS1 DOMAIN PAIR FROM THE INSECT CELL ADHESION MOLECULE FASCICLIN I'''
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===NOVEL FOLD REVEALED BY THE STRUCTURE OF A FAS1 DOMAIN PAIR FROM THE INSECT CELL ADHESION MOLECULE FASCICLIN I===
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==Overview==
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Fasciclin I is an insect neural cell adhesion molecule consisting of four FAS1 domains, homologs of which are present in many bacterial, plant, and animal proteins. The crystal structure of FAS1 domains 3 and 4 of Drosophila fasciclin I reveals a novel domain fold, consisting of a seven-stranded beta wedge and a number of alpha helices. The two domains are arranged in a linear fashion and interact through a substantial polar interface. Missense mutations in the FAS1 domains of the human protein betaig-h3 cause corneal dystrophies. Many mutations alter highly conserved core residues, but the two most common mutations, affecting Arg-124 and Arg-555, map to exposed alpha-helical regions, suggesting reduced protein solubility as the disease mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 12575939 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12575939}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular module]]
[[Category: Extracellular module]]
[[Category: Genetic disorder]]
[[Category: Genetic disorder]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:27:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:59:08 2008''

Revision as of 13:59, 28 July 2008

Image:1o70.png

Template:STRUCTURE 1o70

NOVEL FOLD REVEALED BY THE STRUCTURE OF A FAS1 DOMAIN PAIR FROM THE INSECT CELL ADHESION MOLECULE FASCICLIN I

Template:ABSTRACT PUBMED 12575939

About this Structure

1O70 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Novel fold revealed by the structure of a FAS1 domain pair from the insect cell adhesion molecule fasciclin I., Clout NJ, Tisi D, Hohenester E, Structure. 2003 Feb;11(2):197-203. PMID:12575939

Page seeded by OCA on Mon Jul 28 16:59:08 2008

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