1n94

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[[Image:1n94.gif|left|200px]]
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{{STRUCTURE_1n94| PDB=1n94 | SCENE= }}
{{STRUCTURE_1n94| PDB=1n94 | SCENE= }}
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'''Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates'''
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===Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates===
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==Overview==
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Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12657282 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657282}}
==About this Structure==
==About this Structure==
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[[Category: Farnesyltransferase]]
[[Category: Farnesyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:14:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:00:08 2008''

Revision as of 14:00, 28 July 2008

Image:1n94.png

Template:STRUCTURE 1n94

Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates

Template:ABSTRACT PUBMED 12657282

About this Structure

1N94 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives., Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. PMID:12657282

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