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1qw5

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[[Image:1qw5.jpg|left|200px]]
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{{STRUCTURE_1qw5| PDB=1qw5 | SCENE= }}
{{STRUCTURE_1qw5| PDB=1qw5 | SCENE= }}
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'''Murine inducible nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.'''
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===Murine inducible nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.===
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==Overview==
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The high level of amino acid conservation and structural similarity in the immediate vicinity of the substrate binding sites of the oxygenase domains of the nitric-oxide synthase (NOS) isoforms (eNOSoxy, iNOSoxy, and nNOSoxy) make the interpretation of the structural basis of inhibitor isoform specificity a challenge and provide few clues for the design of new selective compounds. Crystal structures of iNOSoxy and nNOSoxy complexed with the inhibitors W1400 and Nomega-propyl-l-arginine provide a rationale for their isoform specificity. It involves differences outside the immediate active site as well as a conformational flexibility in the active site that allows the adoption of distinct conformations in response to interactions with the inhibitors. This flexibility is determined by isoform-specific residues outside the active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 12954642 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12954642}}
==About this Structure==
==About this Structure==
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[[Category: Schlichting, I.]]
[[Category: Schlichting, I.]]
[[Category: Murine inosoxy inhibitor complex]]
[[Category: Murine inosoxy inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:46:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:00:26 2008''

Revision as of 14:00, 28 July 2008

Image:1qw5.png

Template:STRUCTURE 1qw5

Murine inducible nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.

Template:ABSTRACT PUBMED 12954642

About this Structure

1QW5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms., Fedorov R, Hartmann E, Ghosh DK, Schlichting I, J Biol Chem. 2003 Nov 14;278(46):45818-25. Epub 2003 Sep 3. PMID:12954642

Page seeded by OCA on Mon Jul 28 17:00:26 2008

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