1w9z

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[[Image:1w9z.gif|left|200px]]
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{{Seed}}
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[[Image:1w9z.png|left|200px]]
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{{STRUCTURE_1w9z| PDB=1w9z | SCENE= }}
{{STRUCTURE_1w9z| PDB=1w9z | SCENE= }}
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'''STRUCTURE OF BANNAVIRUS VP9'''
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===STRUCTURE OF BANNAVIRUS VP9===
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==Overview==
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Banna virus (BAV: genus Seadornavirus, family Reoviridae) has a double-shelled morphology similar to rotavirus and bluetongue virus. The structure of BAV outer-capsid protein VP9 was determined by X-ray crystallography at 2.6 A resolution, revealing a trimeric molecule, held together by an N-terminal helical bundle, reminiscent of coiled-coil structures found in fusion-active proteins such as HIV gp41. The major domain of VP9 contains stacked beta sheets with marked structural similarities to the receptor binding protein VP8 of rotavirus. Anti-VP9 antibodies neutralize viral infectivity, and, remarkably, pretreatment of cells with trimeric VP9 increased viral infectivity, indicating that VP9 is involved in virus attachment to cell surface and subsequent internalization. Sequence similarities were also detected between BAV VP10 and VP5 portion of rotavirus VP4, suggesting that the receptor binding and internalization apparatus, which is a single gene product activated by proteoloysis in rotavirus, is the product of two separate genome segments in BAV.
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(as it appears on PubMed at http://www.pubmed.gov), where 15642258 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642258}}
==About this Structure==
==About this Structure==
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[[Category: Dsrna virus]]
[[Category: Dsrna virus]]
[[Category: Outer core protein]]
[[Category: Outer core protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:21:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:00:34 2008''

Revision as of 14:00, 28 July 2008

Image:1w9z.png

Template:STRUCTURE 1w9z

STRUCTURE OF BANNAVIRUS VP9

Template:ABSTRACT PUBMED 15642258

About this Structure

1W9Z is a Single protein structure of sequence from Banna virus. Full crystallographic information is available from OCA.

Reference

The structure and function of the outer coat protein VP9 of Banna virus., Mohd Jaafar F, Attoui H, Bahar MW, Siebold C, Sutton G, Mertens PP, De Micco P, Stuart DI, Grimes JM, De Lamballerie X, Structure. 2005 Jan;13(1):17-28. PMID:15642258

Page seeded by OCA on Mon Jul 28 17:00:34 2008

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