2ojg

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{{STRUCTURE_2ojg| PDB=2ojg | SCENE= }}
{{STRUCTURE_2ojg| PDB=2ojg | SCENE= }}
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'''Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide'''
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===Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide===
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==Overview==
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The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p, a potent and selective inhibitor of ERK.
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(as it appears on PubMed at http://www.pubmed.gov), where 17300186 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17300186}}
==About this Structure==
==About this Structure==
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[[Category: Xie, X.]]
[[Category: Xie, X.]]
[[Category: Kinase inhibitor]]
[[Category: Kinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:02:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:01:07 2008''

Revision as of 14:01, 28 July 2008

Image:2ojg.png

Template:STRUCTURE 2ojg

Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide

Template:ABSTRACT PUBMED 17300186

About this Structure

2OJG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors., Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X, J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186

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