2bdy

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[[Image:2bdy.jpg|left|200px]]
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{{Seed}}
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[[Image:2bdy.png|left|200px]]
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{{STRUCTURE_2bdy| PDB=2bdy | SCENE= }}
{{STRUCTURE_2bdy| PDB=2bdy | SCENE= }}
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'''thrombin in complex with inhibitor'''
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===thrombin in complex with inhibitor===
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==Overview==
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Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_16290930}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16290930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16290930}}
==About this Structure==
==About this Structure==
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[[Category: Complex structure]]
[[Category: Complex structure]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:09:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:03:38 2008''

Revision as of 14:03, 28 July 2008

Template:STRUCTURE 2bdy

thrombin in complex with inhibitor

Template:ABSTRACT PUBMED 16290930

About this Structure

2BDY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure., Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellstrom O, Xue Y, Bioorg Med Chem Lett. 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15. PMID:16290930

Page seeded by OCA on Mon Jul 28 17:03:38 2008

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