2arw

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[[Image:2arw.gif|left|200px]]
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{{Seed}}
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[[Image:2arw.png|left|200px]]
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{{STRUCTURE_2arw| PDB=2arw | SCENE= }}
{{STRUCTURE_2arw| PDB=2arw | SCENE= }}
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'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor'''
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===The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor===
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==Overview==
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The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.
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The line below this paragraph, {{ABSTRACT_PUBMED_16972794}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16972794 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16972794}}
==About this Structure==
==About this Structure==
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2ARW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA].
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2ARW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA].
==Reference==
==Reference==
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[[Category: Schwantner, A.]]
[[Category: Schwantner, A.]]
[[Category: Fibronectin-type iii like]]
[[Category: Fibronectin-type iii like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:24:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:03:44 2008''

Revision as of 14:03, 28 July 2008

Image:2arw.png

Template:STRUCTURE 2arw

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

Template:ABSTRACT PUBMED 16972794

About this Structure

2ARW is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794

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