2boc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2boc.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2boc.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2boc| PDB=2boc | SCENE= }}
{{STRUCTURE_2boc| PDB=2boc | SCENE= }}
-
'''POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)'''
+
===POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)===
-
==Overview==
+
<!--
-
Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15852022}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15852022 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15852022}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Potassium channel]]
[[Category: Potassium channel]]
[[Category: Protein-antibody fab complex]]
[[Category: Protein-antibody fab complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:08:35 2008''

Revision as of 14:08, 28 July 2008

Image:2boc.png

Template:STRUCTURE 2boc

POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRAETHYLARSONIUM (TEAS)

Template:ABSTRACT PUBMED 15852022

About this Structure

2BOC is a Protein complex structure of sequences from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Structural basis of TEA blockade in a model potassium channel., Lenaeus MJ, Vamvouka M, Focia PJ, Gross A, Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022

Page seeded by OCA on Mon Jul 28 17:08:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2boc"
Personal tools