1ur6

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{{STRUCTURE_1ur6| PDB=1ur6 | SCENE= }}
{{STRUCTURE_1ur6| PDB=1ur6 | SCENE= }}
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'''NMR BASED STRUCTURAL MODEL OF THE UBCH5B-CNOT4 COMPLEX'''
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===NMR BASED STRUCTURAL MODEL OF THE UBCH5B-CNOT4 COMPLEX===
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==Overview==
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The protein CNOT4 possesses an N-terminal RING finger domain that acts as an E3 ubiquitin ligase and specifically interacts with UbcH5B, a ubiquitin-conjugating enzyme. The structure of the CNOT4 RING domain has been solved and the amino acids important for the binding to UbcH5B have been mapped. Here, the residues of UbcH5B important for the binding to CNOT4 RING domain were identified by NMR chemical shift perturbation experiments, and these data were used to generate structural models of the complex with the program HADDOCK. Together with the NMR data, additional biochemical data were included in a second docking, and comparisons of the resulting model with the structure of the c-Cbl/UbcH7 complex reveal some significant differences, notably at specific residues, and give structural insights into the E2/E3 specificity.
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{{ABSTRACT_PUBMED_15062086}}
==About this Structure==
==About this Structure==
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1UR6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UR6 OCA].
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1UR6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UR6 OCA].
==Reference==
==Reference==
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[[Category: Ubiquitin conjugating enzyme]]
[[Category: Ubiquitin conjugating enzyme]]
[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:10:57 2008''

Revision as of 14:11, 28 July 2008

Image:1ur6.png

Template:STRUCTURE 1ur6

NMR BASED STRUCTURAL MODEL OF THE UBCH5B-CNOT4 COMPLEX

Template:ABSTRACT PUBMED 15062086

About this Structure

1UR6 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches., Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R, Structure. 2004 Apr;12(4):633-44. PMID:15062086

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