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2o5k

From Proteopedia

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[[Image:2o5k.jpg|left|200px]]
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{{STRUCTURE_2o5k| PDB=2o5k | SCENE= }}
{{STRUCTURE_2o5k| PDB=2o5k | SCENE= }}
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'''Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor'''
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===Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor===
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==Overview==
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A hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3beta with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly potent ATP-competitive inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 17764934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17764934}}
==About this Structure==
==About this Structure==
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[[Category: Gsk3beta]]
[[Category: Gsk3beta]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:21:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:11:39 2008''

Revision as of 14:11, 28 July 2008

Image:2o5k.png

Template:STRUCTURE 2o5k

Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor

Template:ABSTRACT PUBMED 17764934

About this Structure

2O5K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta., Shin D, Lee SC, Heo YS, Lee WY, Cho YS, Kim YE, Hyun YL, Cho JM, Lee YS, Ro S, Bioorg Med Chem Lett. 2007 Oct 15;17(20):5686-9. Epub 2007 Aug 19. PMID:17764934

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