2jxu

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{{STRUCTURE_2jxu| PDB=2jxu | SCENE= }}
{{STRUCTURE_2jxu| PDB=2jxu | SCENE= }}
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'''NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae'''
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===NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae===
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==Overview==
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Klebsiella pneumoniae (KP), a Gram-negative bacterium, is a common cause of hospital-acquired bacterial infections worldwide. Tellurium (Te) compounds, although relatively rare in the environment, have a long history as antimicrobial and therapeutic agents. In bacteria, tellurite (TeO(3) (-2)) resistance is conferred by the ter (Te(r)) operon (terZABCDEF). Here, on the basis of 2593 restraints derived from NMR analysis, we report the NMR structure of TerB protein (151 amino acids) of KP (KP-TerB), which is mainly composed of seven alpha-helices and a 3(10) helix, with helices II to V apparently forming a four-helix bundle. The ensemble of 20 NMR structures was well-defined, with a RMSD of 0.32 +/- 0.06 A for backbone atoms and 1.11 +/- 0.07 A for heavy atoms, respectively. A unique property of the KP-TerB structure is that the positively and negatively charged clusters are formed by the N-terminal positively and C-terminal negatively charged residues, respectively. To the best of our knowledge, the protein sequence and structures of KP-TerB are unique.
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{{ABSTRACT_PUBMED_18305192}}
==About this Structure==
==About this Structure==
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2JXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXU OCA].
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2JXU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXU OCA].
==Reference==
==Reference==
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[[Category: Tellurite resistance protein]]
[[Category: Tellurite resistance protein]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 9 14:39:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:16:21 2008''

Revision as of 14:16, 28 July 2008

Image:2jxu.png

Template:STRUCTURE 2jxu

NMR solution structure of KP-TerB, a tellurite resistance protein from Klebsiella pneumoniae

Template:ABSTRACT PUBMED 18305192

About this Structure

2JXU is a Single protein structure of sequence from Klebsiella pneumoniae. Full experimental information is available from OCA.

Reference

NMR solution structure of KP-TerB, a tellurite-resistance protein from Klebsiella pneumoniae., Chiang SK, Lou YC, Chen C, Protein Sci. 2008 Feb 27;. PMID:18305192

Page seeded by OCA on Mon Jul 28 17:16:21 2008

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