1pzq

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[[Image:1pzq.gif|left|200px]]
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{{STRUCTURE_1pzq| PDB=1pzq | SCENE= }}
{{STRUCTURE_1pzq| PDB=1pzq | SCENE= }}
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'''Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS 2 and DEBS 3: The A domain'''
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===Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS 2 and DEBS 3: The A domain===
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==Overview==
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Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so engineering genes for their biosynthesis to produce variant molecules holds promise for drug discovery. The modular polyketide synthases are particularly amenable to this approach, because each cycle of chain extension is catalyzed by a different module of enzymes, and the modules are arranged within giant multienzyme subunits in the order in which they act. Protein-protein interactions between terminal docking domains of successive multienzymes promote their correct positioning within the assembly line, but because the overall complex is not stable in vitro, the key interactions have not been identified. We present here the NMR solution structure of a 120 residue polypeptide representing a typical pair of such domains, fused at their respective C and N termini: it adopts a stable dimeric structure which reveals the detailed role of these (predominantly helical) domains in docking and dimerization by modular polyketide synthases.
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(as it appears on PubMed at http://www.pubmed.gov), where 12954331 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12954331}}
==About this Structure==
==About this Structure==
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1PZQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZQ OCA].
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1PZQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PZQ OCA].
==Reference==
==Reference==
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[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Homodimer]]
[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:41:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:16:24 2008''

Revision as of 14:16, 28 July 2008

Image:1pzq.png

Template:STRUCTURE 1pzq

Structure of fused docking domains from the erythromycin polyketide synthase (DEBS), a model for the interaction between DEBS 2 and DEBS 3: The A domain

Template:ABSTRACT PUBMED 12954331

About this Structure

1PZQ is a Single protein structure of sequence from Saccharopolyspora erythraea. Full experimental information is available from OCA.

Reference

The structure of docking domains in modular polyketide synthases., Broadhurst RW, Nietlispach D, Wheatcroft MP, Leadlay PF, Weissman KJ, Chem Biol. 2003 Aug;10(8):723-31. PMID:12954331

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