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1whi

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{{STRUCTURE_1whi| PDB=1whi | SCENE= }}
{{STRUCTURE_1whi| PDB=1whi | SCENE= }}
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'''RIBOSOMAL PROTEIN L14'''
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===RIBOSOMAL PROTEIN L14===
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==Overview==
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BACKGROUND: Detailed structural information on ribosomal proteins has increased our understanding of the structure, function and evolution of the ribosome. L14 is one of the most conserved ribosomal proteins and appears to have a central role in the ribonucleoprotein complex. Studies have indicated that L14 occupies a central location between the peptidyl transferase and GTPase regions of the large ribosomal subunit. RESULTS: The crystal structure of L14 from Bacillus stearothermophilus has been solved using a combination of isomorphous replacement and multiwavelength anomalous dispersion (MAD) methods. The structure comprises a five-stranded beta-barrel, a C-terminal loop region that contains two small alpha-helices, and a beta-ribbon that projects from the beta-barrel. An analysis of the structure and the conserved amino acids reveals three surface patches that probably mediate L14-RNA and L14-protein interactions within the ribosome. CONCLUSIONS: The accepted role of ribosomal proteins is to promote the folding and stabilization of ribosomal RNA. The L14 structure is consistent with this notion, and it suggests that the RNA binds in two sites. One RNA-binding site appears to recognize a distinct region of ribosomal RNA during particle assembly. The second site is smaller and may become occupied during the later compaction of the RNA. The surface hydrophobic patch is a likely site of protein-protein interaction, possibly with L19.
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{{ABSTRACT_PUBMED_8805509}}
==About this Structure==
==About this Structure==
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[[Category: Ribosomal protein]]
[[Category: Ribosomal protein]]
[[Category: Rrna-binding]]
[[Category: Rrna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:40:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:17:18 2008''

Revision as of 14:17, 28 July 2008

Image:1whi.png

Template:STRUCTURE 1whi

RIBOSOMAL PROTEIN L14

Template:ABSTRACT PUBMED 8805509

About this Structure

1WHI is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus., Davies C, White SW, Ramakrishnan V, Structure. 1996 Jan 15;4(1):55-66. PMID:8805509

Page seeded by OCA on Mon Jul 28 17:17:18 2008

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