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3bgs

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{{STRUCTURE_3bgs| PDB=3bgs | SCENE= }}
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'''Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate'''
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===Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate===
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==Overview==
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Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.
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{{ABSTRACT_PUBMED_18154341}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transition state analogue]]
[[Category: Transition state analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:44:52 2008''
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Revision as of 14:22, 28 July 2008

Image:3bgs.png

Template:STRUCTURE 3bgs

Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate

Template:ABSTRACT PUBMED 18154341

About this Structure

3BGS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase., Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL, J Am Chem Soc. 2008 Jan 23;130(3):842-4. Epub 2007 Dec 23. PMID:18154341

Page seeded by OCA on Mon Jul 28 17:22:51 2008

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