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1u12

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[[Image:1u12.gif|left|200px]]
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{{STRUCTURE_1u12| PDB=1u12 | SCENE= }}
{{STRUCTURE_1u12| PDB=1u12 | SCENE= }}
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'''M. loti cyclic nucleotide binding domain mutant'''
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===M. loti cyclic nucleotide binding domain mutant===
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==Overview==
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Here we describe the initial functional characterization of a cyclic nucleotide regulated ion channel from the bacterium Mesorhizobium loti and present two structures of its cyclic nucleotide binding domain, with and without cAMP. The domains are organized as dimers with the interface formed by the linker regions that connect the nucleotide binding pocket to the pore domain. Together, structural and functional data suggest the domains form two dimers on the cytoplasmic face of the channel. We propose a model for gating in which ligand binding alters the structural relationship within a dimer, directly affecting the position of the adjacent transmembrane helices.
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The line below this paragraph, {{ABSTRACT_PUBMED_15550244}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15550244 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15550244}}
==About this Structure==
==About this Structure==
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[[Category: Mutant cyclic nucleotide binding domain]]
[[Category: Mutant cyclic nucleotide binding domain]]
[[Category: Unliganded]]
[[Category: Unliganded]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:37:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:25:29 2008''

Revision as of 14:25, 28 July 2008

Image:1u12.png

Template:STRUCTURE 1u12

M. loti cyclic nucleotide binding domain mutant

Template:ABSTRACT PUBMED 15550244

About this Structure

1U12 is a Single protein structure of sequence from Mesorhizobium loti maff303099. Full crystallographic information is available from OCA.

Reference

Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel., Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH, Cell. 2004 Nov 24;119(5):615-27. PMID:15550244

Page seeded by OCA on Mon Jul 28 17:25:29 2008

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