1jzz

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{{Seed}}
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{{STRUCTURE_1jzz| PDB=1jzz | SCENE= }}
{{STRUCTURE_1jzz| PDB=1jzz | SCENE= }}
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'''Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria'''
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===Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria===
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==Overview==
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Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is central to understanding the mechanisms of drug action. Conversely, drugs are excellent tools for studying the ribosome function. To elucidate the structural basis of ribosome-antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the clinically relevant antibiotics chloramphenicol, clindamycin and the three macrolides erythromycin, clarithromycin and roxithromycin. We found that antibiotic binding sites are composed exclusively of segments of 23S ribosomal RNA at the peptidyl transferase cavity and do not involve any interaction of the drugs with ribosomal proteins. Here we report the details of antibiotic interactions with the components of their binding sites. Our results also show the importance of putative Mg+2 ions for the binding of some drugs. This structural analysis should facilitate rational drug design.
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The line below this paragraph, {{ABSTRACT_PUBMED_11677599}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11677599 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11677599}}
==About this Structure==
==About this Structure==
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[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Roxithromycin]]
[[Category: Roxithromycin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:07:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:25:33 2008''

Revision as of 14:25, 28 July 2008

Image:1jzz.png

Template:STRUCTURE 1jzz

Structural Basis for the Interaction of Antibiotics with the Peptidyl Transferase Center in Eubacteria

Template:ABSTRACT PUBMED 11677599

About this Structure

1JZZ is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria., Schlunzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F, Nature. 2001 Oct 25;413(6858):814-21. PMID:11677599

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