1qzt

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{{Seed}}
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{{STRUCTURE_1qzt| PDB=1qzt | SCENE= }}
{{STRUCTURE_1qzt| PDB=1qzt | SCENE= }}
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'''Phosphotransacetylase from Methanosarcina thermophila'''
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===Phosphotransacetylase from Methanosarcina thermophila===
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==Overview==
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Phosphotransacetylase (Pta) [EC 2.3.1.8] is ubiquitous in the carbon assimilation and energy-yielding pathways in anaerobic prokaryotes where it catalyzes the reversible transfer of the acetyl group from acetyl phosphate to CoA forming acetyl CoA and inorganic phosphate. The crystal structure of Pta from the methane-producing archaeon Methanosarcina thermophila, representing the first crystal structure of any Pta, was determined by multiwavelength anomalous diffraction at 2.7 A resolution. In solution and in the crystal, the enzyme forms a homodimer. Each monomer consists of two alpha/beta domains with a cleft along the domain boundary, which presumably contains the substrate binding sites. Comparison of the four monomers present in the asymmetric unit indicates substantial variations in the relative orientation of the two domains and the structure of the putative active site cleft. A search for structural homologs revealed the NADP(+)-dependent isocitrate and isopropylmalate dehydrogenases as the only homologs with a similar two-domain architecture.
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The line below this paragraph, {{ABSTRACT_PUBMED_15062079}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15062079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15062079}}
==About this Structure==
==About this Structure==
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[[Category: Acetate metabolism]]
[[Category: Acetate metabolism]]
[[Category: Acetyl phosphate]]
[[Category: Acetyl phosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:25:48 2008''

Revision as of 14:25, 28 July 2008

Image:1qzt.png

Template:STRUCTURE 1qzt

Phosphotransacetylase from Methanosarcina thermophila

Template:ABSTRACT PUBMED 15062079

About this Structure

1QZT is a Single protein structure of sequence from Methanosarcina thermophila. Full crystallographic information is available from OCA.

Reference

Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:15062079

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