2b6b

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[[Image:2b6b.gif|left|200px]]
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{{Seed}}
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[[Image:2b6b.png|left|200px]]
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{{STRUCTURE_2b6b| PDB=2b6b | SCENE= }}
{{STRUCTURE_2b6b| PDB=2b6b | SCENE= }}
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'''Cryo EM structure of Dengue complexed with CRD of DC-SIGN'''
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===Cryo EM structure of Dengue complexed with CRD of DC-SIGN===
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==Overview==
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Dengue virus (DENV) is a significant human pathogen that causes millions of infections and results in about 24,000 deaths each year. Dendritic cell-specific ICAM3 grabbing nonintegrin (DC-SIGN), abundant in immature dendritic cells, was previously reported as being an ancillary receptor interacting with the surface of DENV. The structure of DENV in complex with the carbohydrate recognition domain (CRD) of DC-SIGN was determined by cryo-electron microscopy at 25 A resolution. One CRD monomer was found to bind to two glycosylation sites at Asn67 of two neighboring glycoproteins in each icosahedral asymmetric unit, leaving the third Asn67 residue vacant. The vacancy at the third Asn67 site is a result of the nonequivalence of the glycoprotein environments, leaving space for the primary receptor binding to domain III of E. The use of carbohydrate moieties for receptor binding sites suggests a mechanism for avoiding immune surveillance.
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The line below this paragraph, {{ABSTRACT_PUBMED_16469696}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16469696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16469696}}
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==Disease==
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Known disease associated with this structure: Dengue fever, protection against OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], HIV type 1, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]], Mycobacterium tuberculosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604672 604672]]
==About this Structure==
==About this Structure==
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[[Category: Cryo em dengue crd dc-sign]]
[[Category: Cryo em dengue crd dc-sign]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:54:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:27:17 2008''

Revision as of 14:27, 28 July 2008

Image:2b6b.png

Template:STRUCTURE 2b6b

Contents

Cryo EM structure of Dengue complexed with CRD of DC-SIGN

Template:ABSTRACT PUBMED 16469696

Disease

Known disease associated with this structure: Dengue fever, protection against OMIM:[604672], HIV type 1, susceptibility to OMIM:[604672], Mycobacterium tuberculosis, susceptibility to OMIM:[604672]

About this Structure

2B6B is a Protein complex structure of sequences from Dengue virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN., Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG, Cell. 2006 Feb 10;124(3):485-93. PMID:16469696

Page seeded by OCA on Mon Jul 28 17:27:17 2008

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