2aph

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[[Image:2aph.gif|left|200px]]
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{{STRUCTURE_2aph| PDB=2aph | SCENE= }}
{{STRUCTURE_2aph| PDB=2aph | SCENE= }}
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'''Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide'''
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===Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide===
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==Overview==
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Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors of the innate immune system that bind bacterial peptidoglycans (PGNs). We determined the crystal structure, to 2.1 A resolution, of the C-terminal PGN-binding domain of human PGRP-I alpha in complex with a muramyl pentapeptide (MPP) from Gram-positive bacteria containing a complete peptide stem (L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala). The structure reveals important features not observed previously in the complex between PGRP-I alpha and a muramyl tripeptide lacking D-Ala at stem positions 4 and 5. Most notable are ligand-induced structural rearrangements in the PGN-binding site that are essential for entry of the C-terminal portion of the peptide stem and for locking MPP in the binding groove. We propose that similar structural rearrangements to accommodate the PGN stem likely characterize many PGRPs, both mammalian and insect.
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(as it appears on PubMed at http://www.pubmed.gov), where 16641493 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16641493}}
==About this Structure==
==About this Structure==
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[[Category: Peptidoglycan]]
[[Category: Peptidoglycan]]
[[Category: Pgrp]]
[[Category: Pgrp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:19:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:30:49 2008''

Revision as of 14:30, 28 July 2008

Image:2aph.png

Template:STRUCTURE 2aph

Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide

Template:ABSTRACT PUBMED 16641493

About this Structure

2APH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria., Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA, Protein Sci. 2006 May;15(5):1199-206. PMID:16641493

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