3enr

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{{STRUCTURE_3enr| PDB=3enr | SCENE= }}
{{STRUCTURE_3enr| PDB=3enr | SCENE= }}
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'''ZINC-CALCIUM CONCANAVALIN A AT PH 6.15'''
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===ZINC-CALCIUM CONCANAVALIN A AT PH 6.15===
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==Overview==
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The crystal structures of cadmium/cadmium and zinc/calcium concanavalin A (con A) at pH 5.0 and pH 6.15, respectively, were determined. The structure of cadmium/cadmium con A confirms that the secondary Cd(2+)-binding site S3 is empty at pH 5. The metal-binding sites S1 and S2 are only very slightly affected by the substitution with cadmium. On the other hand, S1 and S2 and most of the protein surface of zinc/calcium con A at pH 6.15 differ from other fully metal-bound and carbohydrate-free structures. Most of these structural differences at the protein surface are a result of the interplay between metal binding, protonation and crystal packing. This interplay is expressed by relative rotations and translations of the con A units in alternative crystal packings and participation in space-group conversions inside crystals in situ. The particular crystal packing of zinc/calcium con A creates a novel zinc-binding site S4. The Zn(2+) ion in S4 ligates two aspartates from one tetramer and a histidine from a symmetry-related tetramer.
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{{ABSTRACT_PUBMED_11092923}}
==About this Structure==
==About this Structure==
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[[Category: Metal binding]]
[[Category: Metal binding]]
[[Category: Ph]]
[[Category: Ph]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:33:15 2008''

Revision as of 14:33, 28 July 2008

Image:3enr.png

Template:STRUCTURE 3enr

ZINC-CALCIUM CONCANAVALIN A AT PH 6.15

Template:ABSTRACT PUBMED 11092923

About this Structure

3ENR is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

Zinc/calcium- and cadmium/cadmium-substituted concanavalin A: interplay of metal binding, pH and molecular packing., Bouckaert J, Loris R, Wyns L, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1569-76. PMID:11092923

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