1rj8

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[[Image:1rj8.gif|left|200px]]
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{{STRUCTURE_1rj8| PDB=1rj8 | SCENE= }}
{{STRUCTURE_1rj8| PDB=1rj8 | SCENE= }}
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'''The crystal structure of TNF family member EDA-A2'''
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===The crystal structure of TNF family member EDA-A2===
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==Overview==
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EDA is a tumor necrosis factor family member involved in ectodermal development. Splice variants EDA-A1 and EDA-A2 differ only by the presence of Glu 308 and Val 309 in the expected receptor binding region of EDA-A1 but not EDA-A2. This two amino acid difference functions as a switch controlling receptor specificity. EDA-A1 binds only to EDAR, while EDA-A2 is specific for XEDAR. In order to understand the structural basis of this switch, we determined the X-ray crystal structures of the TNF domain of both EDA-A1 and EDA-A2 at 2.3 A and 2.2 A, respectively. While the backbone conformation around the splice difference is similar in both isoforms, the conformation of the following loop, the surface charge, and the shape of the expected receptor binding site differ significantly.
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(as it appears on PubMed at http://www.pubmed.gov), where 14656435 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656435}}
==About this Structure==
==About this Structure==
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[[Category: Tnf domain]]
[[Category: Tnf domain]]
[[Category: Trimer]]
[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:33:35 2008''

Revision as of 14:33, 28 July 2008

Image:1rj8.png

Template:STRUCTURE 1rj8

The crystal structure of TNF family member EDA-A2

Template:ABSTRACT PUBMED 14656435

About this Structure

1RJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity., Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM, Structure. 2003 Dec;11(12):1513-20. PMID:14656435

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