2az8

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{{STRUCTURE_2az8| PDB=2az8 | SCENE= }}
{{STRUCTURE_2az8| PDB=2az8 | SCENE= }}
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'''HIV-1 Protease NL4-3 in complex with inhibitor, TL-3'''
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===HIV-1 Protease NL4-3 in complex with inhibitor, TL-3===
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==Overview==
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The development of resistance to anti-retroviral drugs targeted against HIV is an increasing clinical problem in the treatment of HIV-1-infected individuals. Many patients develop drug-resistant strains of the virus after treatment with inhibitor cocktails (HAART therapy), which include multiple protease inhibitors. Therefore, it is imperative that we understand the mechanisms by which the viral proteins, in particular HIV-1 protease, develop resistance. We have determined the three-dimensional structure of HIV-1 protease NL4-3 in complex with the potent protease inhibitor TL-3 at 2.0 A resolution. We have also obtained the crystal structures of three mutant forms of NL4-3 protease containing one (V82A), three (V82A, M46I, F53L) and six (V82A, M46I, F53L, V77I, L24I, L63P) point mutations in complex with TL-3. The three protease mutants arose sequentially under ex vivo selective pressure in the presence of TL-3, and exhibit fourfold, 11-fold, and 30-fold resistance to TL-3, respectively. This series of protease crystal structures offers insights into the biochemical and structural mechanisms by which the enzyme can overcome inhibition by TL-3 while recovering some of its native catalytic activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16403521 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16403521}}
==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Tl-3]]
[[Category: Tl-3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:39:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:33:54 2008''

Revision as of 14:33, 28 July 2008

Image:2az8.png

Template:STRUCTURE 2az8

HIV-1 Protease NL4-3 in complex with inhibitor, TL-3

Template:ABSTRACT PUBMED 16403521

About this Structure

2AZ8 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3., Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD, J Mol Biol. 2006 Mar 3;356(4):967-81. Epub 2005 Dec 20. PMID:16403521

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