2qv2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2qv2.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2qv2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2qv2| PDB=2qv2 | SCENE= }}
{{STRUCTURE_2qv2| PDB=2qv2 | SCENE= }}
-
'''A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway'''
+
===A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway===
-
==Overview==
+
<!--
-
Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, whose manifestations include mental retardation and renal Fanconi syndrome. OCRL has been implicated in membrane trafficking, but disease mechanisms remain unclear. We show that OCRL visits late-stage, endocytic clathrin-coated pits and binds the Rab5 effector APPL1 on peripheral early endosomes. The interaction with APPL1, which is mediated by the ASH-RhoGAP-like domains of OCRL and is abolished by disease mutations, provides a link to protein networks implicated in the reabsorptive function of the kidney and in the trafficking and signaling of growth factor receptors in the brain. Crystallographic studies reveal a role of the ASH-RhoGAP-like domains in positioning the phosphatase domain at the membrane interface and a clathrin box protruding from the RhoGAP-like domain. Our results support a role of OCRL in the early endocytic pathway, consistent with the predominant localization of its preferred substrates, PI(4,5)P(2) and PI(3,4,5)P(3), at the cell surface.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17765681}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17765681 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17765681}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Phosphoinositide]]
[[Category: Phosphoinositide]]
[[Category: Rhogap]]
[[Category: Rhogap]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:44:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:40:27 2008''

Revision as of 14:40, 28 July 2008

Image:2qv2.png

Template:STRUCTURE 2qv2

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

Template:ABSTRACT PUBMED 17765681

About this Structure

2QV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway., Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P, Dev Cell. 2007 Sep;13(3):377-90. PMID:17765681

Page seeded by OCA on Mon Jul 28 17:40:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qv2"
Personal tools