1w7z

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[[Image:1w7z.gif|left|200px]]
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{{Seed}}
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[[Image:1w7z.png|left|200px]]
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{{STRUCTURE_1w7z| PDB=1w7z | SCENE= }}
{{STRUCTURE_1w7z| PDB=1w7z | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)'''
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===CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)===
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==Overview==
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The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with trypsin have also been determined, one carrying a four-amino-acid mutation of EETI-II. The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold.
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The line below this paragraph, {{ABSTRACT_PUBMED_16131759}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16131759 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16131759}}
==About this Structure==
==About this Structure==
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[[Category: Squash seed inhibitor]]
[[Category: Squash seed inhibitor]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:16:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:41:46 2008''

Revision as of 14:41, 28 July 2008

Image:1w7z.png

Template:STRUCTURE 1w7z

CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)

Template:ABSTRACT PUBMED 16131759

About this Structure

1W7Z is a Single protein structure of sequence from Ecballium elaterium. Full crystallographic information is available from OCA.

Reference

Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold., Kratzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1255-62. Epub 2005, Aug 16. PMID:16131759

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