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1s3k

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{{STRUCTURE_1s3k| PDB=1s3k | SCENE= }}
{{STRUCTURE_1s3k| PDB=1s3k | SCENE= }}
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'''Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide'''
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===Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide===
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==Overview==
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Antibodies targeting human epithelial carcinomas bearing Lewis Y (Le(y)) carbohydrate antigens provide a striking illustration of convergent immune recognition. We report a 1.9A resolution crystal structure of the Fab of a humanized antibody (hu3S193) in complex with the Le(y) tetrasaccharide, Fuc(alpha 1--&gt;2)Gal(beta 1--&gt;4)[Fuc(alpha 1--&gt;3)]GlcNAc. Comparisons of the hu3S193 and BR96 antibodies bound to Le(y) tumor antigens revealed extremely similar mechanisms for recognition of the carbohydrate epitopes. Solvent plays a critical role in hu3S193 antibody binding to the Le(y) carbohydrate epitope. Specificity for Le(y) is maintained because a conserved pocket accepts an N-acetyl group of the core Gal(beta 1--&gt;4)GlcNAc disaccharide. Closely related blood-group determinants (Le(a) and Le(b)) cannot enter the specificity pocket, making the Le(y) antibodies promising candidates for immunotherapy of epithelial cancer.
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(as it appears on PubMed at http://www.pubmed.gov), where 15223322 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15223322}}
==About this Structure==
==About this Structure==
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[[Category: Humanized antibody]]
[[Category: Humanized antibody]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:15:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:50:23 2008''

Revision as of 14:50, 28 July 2008

Image:1s3k.png

Template:STRUCTURE 1s3k

Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide

Template:ABSTRACT PUBMED 15223322

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural convergence of antibody binding of carbohydrate determinants in Lewis Y tumor antigens., Ramsland PA, Farrugia W, Bradford TM, Mark Hogarth P, Scott AM, J Mol Biol. 2004 Jul 16;340(4):809-18. PMID:15223322

Page seeded by OCA on Mon Jul 28 17:50:23 2008

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