2odx

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[[Image:2odx.gif|left|200px]]
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{{STRUCTURE_2odx| PDB=2odx | SCENE= }}
{{STRUCTURE_2odx| PDB=2odx | SCENE= }}
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'''Solution structure of Zn(II)Cox4'''
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===Solution structure of Zn(II)Cox4===
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==Overview==
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Yeast Cox4 is a zinc binding subunit of cytochrome c oxidase. Cox4 is the only cofactor-containing subunit that is not directly part of the catalytic core of the enzyme located in the mitochondrial inner membrane. The Zn(II) site is shown to be distinct from the bovine ortholog, as it results from the x-ray structure of the entire cytochrome c oxidase in having a single histidyl residue and three conserved cysteines residues in the coordination sphere. Substitutions at the Cys ligand positions result in non-functional Cox4 proteins that fail to lead to cytochrome oxidase assembly. Limited function exists in His-119 mutants when overexpressed. Zn(II) binding in Cox4 is, therefore, important for the stability of the complex. The solution structure of yeast Cox4 elucidated by multidimensional NMR reveals a C-terminal globular domain consisting of two beta sheets analogous to the bovine ortholog except the loop containing the coordinating His in the yeast protein and the fourth Cys in the bovine protein are in different positions in the two structures. The conformation of this loop is dictated by the different sequence position of the fourth coordinating zinc ligand. The Zn(II) ion is buried within the domain, consistent with its role in structural stability. Potential functions of this matrix-facing subunit are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_17215247}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17215247 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17215247}}
==About this Structure==
==About this Structure==
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2ODX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODX OCA].
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2ODX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODX OCA].
==Reference==
==Reference==
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[[Category: All beta-protein]]
[[Category: All beta-protein]]
[[Category: Metallo-protein]]
[[Category: Metallo-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:42:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:52:05 2008''

Revision as of 14:52, 28 July 2008

Image:2odx.png

Template:STRUCTURE 2odx

Solution structure of Zn(II)Cox4

Template:ABSTRACT PUBMED 17215247

About this Structure

2ODX is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

The characterization and role of zinc binding in yeast Cox4., Coyne HJ 3rd, Ciofi-Baffoni S, Banci L, Bertini I, Zhang L, George GN, Winge DR, J Biol Chem. 2007 Mar 23;282(12):8926-34. Epub 2007 Jan 10. PMID:17215247

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