This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1nh7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 +
{{Seed}}
[[Image:1nh7.gif|left|200px]]
[[Image:1nh7.gif|left|200px]]
Line 9: Line 10:
{{STRUCTURE_1nh7| PDB=1nh7 | SCENE= }}
{{STRUCTURE_1nh7| PDB=1nh7 | SCENE= }}
-
'''ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS'''
+
===ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS===
-
==Overview==
+
<!--
-
The N-1-(5'-phosphoribosyl)-ATP transferase catalyzes the first step of the histidine biosynthetic pathway and is regulated by a feedback mechanism by the product histidine. The crystal structures of the N-1-(5'-phosphoribosyl)-ATP transferase from Mycobacterium tuberculosis in complex with inhibitor histidine and AMP has been determined to 1.8 A resolution and without ligands to 2.7 A resolution. The active enzyme exists primarily as a dimer, and the histidine-inhibited form is a hexamer. The structure represents a new fold for a phosphoribosyltransferase, consisting of three continuous domains. The inhibitor AMP binds in the active site cavity formed between the two catalytic domains. A model for the mechanism of allosteric inhibition has been derived from conformational differences between the AMP:His-bound and apo structures.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12511575}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12511575 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12511575}}
==About this Structure==
==About this Structure==
Line 38: Line 42:
[[Category: Tbsgc]]
[[Category: Tbsgc]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:31:37 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:30:12 2008''

Revision as of 15:30, 28 July 2008

Image:1nh7.gif

Template:STRUCTURE 1nh7

ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS

Template:ABSTRACT PUBMED 12511575

About this Structure

1NH7 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis., Cho Y, Sharma V, Sacchettini JC, J Biol Chem. 2003 Mar 7;278(10):8333-9. Epub 2003 Jan 2. PMID:12511575

Page seeded by OCA on Mon Jul 28 18:30:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nh7"
Personal tools