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2ch1
From Proteopedia
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(New page: 200px<br /> <applet load="2ch1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ch1, resolution 2.40Å" /> '''STRUCTURE OF ANOPHE...)
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Revision as of 18:30, 29 October 2007
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STRUCTURE OF ANOPHELES GAMBIAE 3-HYDROXYKYNURENINE TRANSAMINASE
Overview
In Anopheles gambiae, the vector for the most deadly malaria parasite, Plasmodium falciparum, xanthurenic acid (XA) plays a key role in parasite, gametogenesis and fertility. In mosquitoes, XA is produced by, transamination of 3-hydroxykynurenine (3-HK), a reaction that represents, the main route to prevent the accumulation of the potentially toxic 3-HK, excess. Interfering with XA metabolism in A. gambiae therefore appears an, attractive avenue for the development of malaria transmission-blocking, drugs and insecticides. We have determined the crystal structure of A., gambiae 3-HK transaminase in its pyridoxal 5'-phosphate form and in, complex with a newly synthesized competitive enzyme inhibitor. Structural, inspection of the enzyme active site reveals the key molecular, determinants ... [(full description)]
About this Structure
2CH1 is a [Single protein] structure of sequence from [Anopheles gambiae] with LLP and GOL as [ligands]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase., Rossi F, Garavaglia S, Giovenzana GB, Arca B, Li J, Rizzi M, Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5711-6. Epub 2006 Apr 3. PMID:16585514
Page seeded by OCA on Mon Oct 29 20:35:28 2007
