1n6v

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[[Image:1n6v.gif|left|200px]]
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{{STRUCTURE_1n6v| PDB=1n6v | SCENE= }}
{{STRUCTURE_1n6v| PDB=1n6v | SCENE= }}
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'''Average structure of the interferon-binding ectodomain of the human type I interferon receptor'''
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===Average structure of the interferon-binding ectodomain of the human type I interferon receptor===
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==Overview==
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The potent antiviral and antiproliferative activities of human type I interferons (IFNs) are mediated by a single receptor comprising two subunits, IFNAR1 and IFNAR2. The structure of the IFNAR2 IFN binding ectodomain (IFNAR2-EC), the first helical cytokine receptor structure determined in solution, reveals the molecular basis for IFN binding. The atypical perpendicular orientation of its two fibronectin domains explains the lack of C domain involvement in ligand binding. A model of the IFNAR2-EC/IFNalpha2 complex based on double mutant cycle-derived constraints uncovers an extensive and predominantly aliphatic hydrophobic patch on the receptor that interacts with a matching hydrophobic surface of IFNalpha2. An adjacent motif of alternating charged side chains guides the two proteins into a tight complex. The binding interface may account for crossreactivity and ligand specificity of the receptor. This molecular description of IFN binding should be invaluable for study and design of IFN-based biomedical agents.
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The line below this paragraph, {{ABSTRACT_PUBMED_12842042}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12842042 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12842042}}
==About this Structure==
==About this Structure==
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1N6V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6V OCA].
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1N6V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N6V OCA].
==Reference==
==Reference==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Two-domain structure]]
[[Category: Two-domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:10:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:33:27 2008''

Revision as of 15:33, 28 July 2008

Image:1n6v.gif

Template:STRUCTURE 1n6v

Average structure of the interferon-binding ectodomain of the human type I interferon receptor

Template:ABSTRACT PUBMED 12842042

About this Structure

1N6V is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding., Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J, Structure. 2003 Jul;11(7):791-802. PMID:12842042

Page seeded by OCA on Mon Jul 28 18:33:27 2008

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