1tf7

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'''Crystal Structure of Circadian Clock Protein KaiC'''
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===Crystal Structure of Circadian Clock Protein KaiC===
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==Overview==
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Circadian (daily) biological clocks express characteristics that are difficult to explain by known biochemical mechanisms, and will ultimately require characterizing the structures, functions, and interactions of their molecular components. KaiC is an essential circadian protein in cyanobacteria that forms the core of the KaiABC clock protein complex. We report the crystal structure of the KaiC homohexameric complex at 2.8 A resolution. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression.
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{{ABSTRACT_PUBMED_15304218}}
==About this Structure==
==About this Structure==
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[[Category: Hexamer]]
[[Category: Hexamer]]
[[Category: Homohexamer]]
[[Category: Homohexamer]]
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Revision as of 15:43, 28 July 2008

Template:STRUCTURE 1tf7

Crystal Structure of Circadian Clock Protein KaiC

Template:ABSTRACT PUBMED 15304218

About this Structure

1TF7 is a Single protein structure of sequence from Synechococcus sp.. Full crystallographic information is available from OCA.

Reference

Visualizing a circadian clock protein: crystal structure of KaiC and functional insights., Pattanayek R, Wang J, Mori T, Xu Y, Johnson CH, Egli M, Mol Cell. 2004 Aug 13;15(3):375-88. PMID:15304218

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