1nvp

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[[Image:1nvp.gif|left|200px]]
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{{STRUCTURE_1nvp| PDB=1nvp | SCENE= }}
{{STRUCTURE_1nvp| PDB=1nvp | SCENE= }}
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'''HUMAN TFIIA/TBP/DNA COMPLEX'''
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===HUMAN TFIIA/TBP/DNA COMPLEX===
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==Overview==
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RNA polymerase II-dependent transcription requires the assembly of a multi-protein, preinitiation complex on core promoter elements. Transcription factor IID (TFIID) comprising the TATA box-binding protein (TBP) and TBP-associated factors (TAFs) is responsible for promoter recognition in this complex. Subsequent association of TFIIA and TFIIB provides enhanced complex stability. TFIIA is required for transcriptional stimulation by certain viral and cellular activators, and favors formation of the preinitiation complex in the presence of repressor NC2. The X-ray structures of human and yeast TBP/TFIIA/DNA complexes at 2.1A and 1.9A resolution, respectively, are presented here and seen to resemble each other closely. The interactions made by human TFIIA with TBP and DNA within and upstream of the TATA box, including those involving water molecules, are described and compared to the yeast structure. Of particular interest is a previously unobserved region of TFIIA that extends the binding interface with TBP in the yeast, but not in the human complex, and that further elucidates biochemical and genetic results.
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The line below this paragraph, {{ABSTRACT_PUBMED_12972251}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12972251 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12972251}}
==About this Structure==
==About this Structure==
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[[Category: Dna]]
[[Category: Dna]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:02:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:44:36 2008''

Revision as of 15:44, 28 July 2008

Image:1nvp.gif

Template:STRUCTURE 1nvp

HUMAN TFIIA/TBP/DNA COMPLEX

Template:ABSTRACT PUBMED 12972251

About this Structure

1NVP is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes., Bleichenbacher M, Tan S, Richmond TJ, J Mol Biol. 2003 Sep 26;332(4):783-93. PMID:12972251

Page seeded by OCA on Mon Jul 28 18:44:36 2008

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