2rp5

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{{STRUCTURE_2rp5| PDB=2rp5 | SCENE= }}
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'''Solution structure of the oligomerization domain in CEP-1'''
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===Solution structure of the oligomerization domain in CEP-1===
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==Overview==
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The tetrameric state of p53, p63, and p73 has been considered one of the hallmarks of this protein family. While the DNA binding domain (DBD) is highly conserved among vertebrates and invertebrates, sequences C-terminal to the DBD are highly divergent. In particular, the oligomerization domain (OD) of the p53 forms of the model organisms Caenorhabditis elegans and Drosophila cannot be identified by sequence analysis. Here, we present the solution structures of their ODs and show that they both differ significantly from each other as well as from human p53. CEP-1 contains a composite domain of an OD and a sterile alpha motif (SAM) domain, and forms dimers instead of tetramers. The Dmp53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix. Truncation analysis in both domains reveals that the additional structural elements are necessary to stabilize the structure of the OD, suggesting a new function for the SAM domain. Furthermore, these structures show a potential path of evolution from an ancestral dimeric form over a tetrameric form, with additional stabilization elements, to the tetramerization domain of mammalian p53.
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{{ABSTRACT_PUBMED_17581633}}
==About this Structure==
==About this Structure==
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2RP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].
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2RP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RP5 OCA].
==Reference==
==Reference==
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[[Category: Sam domain]]
[[Category: Sam domain]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:15:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:45:00 2008''

Revision as of 15:45, 28 July 2008

Image:2rp5.jpg

Template:STRUCTURE 2rp5

Solution structure of the oligomerization domain in CEP-1

Template:ABSTRACT PUBMED 17581633

About this Structure

2RP5 is a Single protein structure of sequence from Caenorhabditis elegans. Full experimental information is available from OCA.

Reference

Structural evolution of C-terminal domains in the p53 family., Ou HD, Lohr F, Vogel V, Mantele W, Dotsch V, EMBO J. 2007 Jul 25;26(14):3463-73. Epub 2007 Jun 21. PMID:17581633

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