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1s6r

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[[Image:1s6r.gif|left|200px]]
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{{Seed}}
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[[Image:1s6r.png|left|200px]]
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{{STRUCTURE_1s6r| PDB=1s6r | SCENE= }}
{{STRUCTURE_1s6r| PDB=1s6r | SCENE= }}
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'''908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID'''
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===908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID===
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==Overview==
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The structures of the class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a boronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 A, respectively. The structure of the enzyme resembles those of other class C beta-lactamases. The structure of the complex with the transition-state analogue, iodo-acetamido-phenyl boronic acid, shows that the inhibitor is covalently bound to the active-site serine (Ser64). Binding of the inhibitor within the active site is compared with previously determined structures of complexes with other class C enzymes. The structure of the boronic acid adduct indicates ways to improve the affinity of this class of inhibitors. This structure of 908R class C beta-lactamase in complex with a transition-state analogue provides further insights into the mechanism of action of these hydrolases.
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(as it appears on PubMed at http://www.pubmed.gov), where 14521155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14521155}}
==About this Structure==
==About this Structure==
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[[Category: Wouters, J.]]
[[Category: Wouters, J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:22:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:46:55 2008''

Revision as of 15:46, 28 July 2008

Image:1s6r.png

Template:STRUCTURE 1s6r

908R CLASS C BETA-LACTAMASE BOUND TO IODO-ACETAMIDO-PHENYL BORONIC ACID

Template:ABSTRACT PUBMED 14521155

About this Structure

1S6R is a Single protein structure of sequence from Enterobacter cloacae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue., Wouters J, Fonze E, Vermeire M, Frere JM, Charlier P, Cell Mol Life Sci. 2003 Aug;60(8):1764-73. PMID:14521155

Page seeded by OCA on Mon Jul 28 18:46:55 2008

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