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2qki

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{{STRUCTURE_2qki| PDB=2qki | SCENE= }}
{{STRUCTURE_2qki| PDB=2qki | SCENE= }}
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'''Human C3c in complex with the inhibitor compstatin'''
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===Human C3c in complex with the inhibitor compstatin===
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==Overview==
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Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is an effective inhibitor of the activation of complement component C3 and thus blocks a central and crucial step in the complement cascade. The precise binding site on C3, the structure in the bound form, and the exact mode of action of compstatin are unknown. Here we present the crystal structure of compstatin in complex with C3c, a major proteolytic fragment of C3. The structure reveals that the compstatin-binding site is formed by the macroglobulin (MG) domains 4 and 5. This binding site is part of the structurally stable MG-ring formed by domains MG 1-6 and is far away from any other known binding site on C3. Compstatin does not alter the conformation of C3c, whereas compstatin itself undergoes a large conformational change upon binding. We propose a model in which compstatin sterically hinders the access of the substrate C3 to the convertase complexes, thus blocking complement activation and amplification. These insights are instrumental for further development of compstatin as a potential therapeutic.
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(as it appears on PubMed at http://www.pubmed.gov), where 17684013 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17684013}}
==About this Structure==
==About this Structure==
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[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Immunity]]
[[Category: Immunity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:07:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:47:04 2008''

Revision as of 15:47, 28 July 2008

Image:2qki.png

Template:STRUCTURE 2qki

Human C3c in complex with the inhibitor compstatin

Template:ABSTRACT PUBMED 17684013

About this Structure

2QKI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition., Janssen BJ, Halff EF, Lambris JD, Gros P, J Biol Chem. 2007 Oct 5;282(40):29241-7. Epub 2007 Aug 6. PMID:17684013

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