1zzj

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{{STRUCTURE_1zzj| PDB=1zzj | SCENE= }}
{{STRUCTURE_1zzj| PDB=1zzj | SCENE= }}
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'''Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA'''
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===Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA===
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==Overview==
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The heterogeneous nuclear ribonucleoprotein (hnRNP) K is implicated in multiple functions in the regulation of gene expression and acts as a hub at the intersection of signaling pathways and processes involving nucleic acids. Central to its function is its ability to bind both ssDNA and ssRNA via its KH (hnRNP K homology) domains. We determined crystal structures of hnRNP K KH3 domain complexed with 15-mer and 6-mer (CTC(4)) ssDNAs at 2.4 and 1.8 A resolution, respectively, and show that the KH3 domain binds specifically to both TCCC and CCCC sequences. In parallel, we used NMR to compare the binding affinity and mode of interaction of the KH3 domain with several ssRNA ligands and CTC(4) ssDNA. Based on a structure alignment of the KH3-CTC(4) complex with known structures of other KH domains in complex with ssRNA, we discuss recognition of tetranucleotide sequences by KH domains.
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The line below this paragraph, {{ABSTRACT_PUBMED_16004877}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16004877 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16004877}}
==About this Structure==
==About this Structure==
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[[Category: Sattler, M.]]
[[Category: Sattler, M.]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:16:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:02 2008''

Revision as of 15:48, 28 July 2008

Image:1zzj.png

Template:STRUCTURE 1zzj

Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA

Template:ABSTRACT PUBMED 16004877

About this Structure

1ZZJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids., Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S, Structure. 2005 Jul;13(7):1055-67. PMID:16004877

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