1pl8

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[[Image:1pl8.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1pl8| PDB=1pl8 | SCENE= }}
{{STRUCTURE_1pl8| PDB=1pl8 | SCENE= }}
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'''human SDH/NAD+ complex'''
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===human SDH/NAD+ complex===
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==Overview==
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Sorbitol dehydrogenase (hSDH) and aldose reductase form the polyol pathway that interconverts glucose and fructose. Redox changes from overproduction of the coenzyme NADH by SDH may play a role in diabetes-induced dysfunction in sensitive tissues, making SDH a therapeutic target for diabetic complications. We have purified and determined the crystal structures of human SDH alone, SDH with NAD(+), and SDH with NADH and an inhibitor that is competitive with fructose. hSDH is a tetramer of identical, catalytically active subunits. In the apo and NAD(+) complex, the catalytic zinc is coordinated by His69, Cys44, Glu70, and a water molecule. The inhibitor coordinates the zinc through an oxygen and a nitrogen atom with the concomitant dissociation of Glu70. The inhibitor forms hydrophobic interactions to NADH and likely sterically occludes substrate binding. The structure of the inhibitor complex provides a framework for developing more potent inhibitors of hSDH.
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The line below this paragraph, {{ABSTRACT_PUBMED_12962626}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12962626 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12962626}}
==About this Structure==
==About this Structure==
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[[Category: Human sorbitol dehydrogenase]]
[[Category: Human sorbitol dehydrogenase]]
[[Category: Nad]]
[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:12:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:08 2008''

Revision as of 15:48, 28 July 2008

Image:1pl8.png

Template:STRUCTURE 1pl8

human SDH/NAD+ complex

Template:ABSTRACT PUBMED 12962626

About this Structure

1PL8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase., Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL, Structure. 2003 Sep;11(9):1071-85. PMID:12962626

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