1nkw
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(New page: 200px<br /><applet load="1nkw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nkw, resolution 3.10Å" /> '''Crystal Structure Of...)
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Revision as of 20:13, 20 November 2007
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Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans
Overview
We describe the high resolution structure of the large ribosomal subunit, from Deinococcus radiodurans (D50S), a gram-positive mesophile suitable, for binding of antibiotics and functionally relevant ligands. The over-all, structure of D50S is similar to that from the archae bacterium Haloarcula, marismortui (H50S); however, a detailed comparison revealed significant, differences, for example, in the orientation of nucleotides in peptidyl, transferase center and in the structures of many ribosomal proteins., Analysis of ribosomal features involved in dynamic aspects of protein, biosynthesis that are partially or fully disordered in H50S revealed the, conformations of intersubunit bridges in unbound subunits, suggesting how, they may change upon subunit association and how movements of the L1-stalk, may facilitate the exit of tRNA.
About this Structure
1NKW is a Protein complex structure of sequences from Deinococcus radiodurans. This structure superseeds the now removed PDB entries 1LNR, 1KPJ and 1KC9. Full crystallographic information is available from OCA.
Reference
High resolution structure of the large ribosomal subunit from a mesophilic eubacterium., Harms J, Schluenzen F, Zarivach R, Bashan A, Gat S, Agmon I, Bartels H, Franceschi F, Yonath A, Cell. 2001 Nov 30;107(5):679-88. PMID:11733066
Page seeded by OCA on Tue Nov 20 22:20:44 2007
