2auh

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{{STRUCTURE_2auh| PDB=2auh | SCENE= }}
{{STRUCTURE_2auh| PDB=2auh | SCENE= }}
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'''Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase'''
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===Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase===
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==Overview==
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Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2) domain, and an intervening stretch of approximately 45 residues known as the BPS region, which is unique to this adaptor family. Previous studies have demonstrated that Grb14 is a tissue-specific negative regulator of insulin receptor signaling and that inhibition is mediated by the BPS region. We have determined the crystal structure of the Grb14 BPS region in complex with the tyrosine kinase domain of the insulin receptor. The structure reveals that the N-terminal portion of the BPS region binds as a pseudosubstrate inhibitor in the substrate peptide binding groove of the kinase. Together with the crystal structure of the SH2 domain, we present a model for the interaction of Grb14 with the insulin receptor, which indicates how Grb14 functions as a selective protein inhibitor of insulin signaling.
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{{ABSTRACT_PUBMED_16246733}}
==Disease==
==Disease==
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[[Category: Bps region]]
[[Category: Bps region]]
[[Category: Yrosine kinase]]
[[Category: Yrosine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:29:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:52:30 2008''

Revision as of 15:52, 28 July 2008

Image:2auh.png

Template:STRUCTURE 2auh

Contents

Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase

Template:ABSTRACT PUBMED 16246733

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this Structure

2AUH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14., Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR, Mol Cell. 2005 Oct 28;20(2):325-33. PMID:16246733

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