2e2b

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{{STRUCTURE_2e2b| PDB=2e2b | SCENE= }}
{{STRUCTURE_2e2b| PDB=2e2b | SCENE= }}
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'''Crystal structure of the c-Abl kinase domain in complex with INNO-406'''
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===Crystal structure of the c-Abl kinase domain in complex with INNO-406===
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==Overview==
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To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity relationship study with the aid of a newly determined X-ray structure of the Abl/Lyn dual inhibitor INNO-406 (formerly known as NS-187) bound to human Abl. We found that this series of compounds interacted with both kinases in very similar ways, so that they can inhibit both kinases effectively.
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(as it appears on PubMed at http://www.pubmed.gov), where 17376680 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17376680}}
==About this Structure==
==About this Structure==
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[[Category: Inno-406]]
[[Category: Inno-406]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:47:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:53:58 2008''

Revision as of 15:54, 28 July 2008

Image:2e2b.png

Template:STRUCTURE 2e2b

Crystal structure of the c-Abl kinase domain in complex with INNO-406

Template:ABSTRACT PUBMED 17376680

About this Structure

2E2B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives., Horio T, Hamasaki T, Inoue T, Wakayama T, Itou S, Naito H, Asaki T, Hayase H, Niwa T, Bioorg Med Chem Lett. 2007 May 15;17(10):2712-7. Epub 2007 Mar 3. PMID:17376680

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