1u5l

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[[Image:1u5l.gif|left|200px]]
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{{Seed}}
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[[Image:1u5l.png|left|200px]]
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{{STRUCTURE_1u5l| PDB=1u5l | SCENE= }}
{{STRUCTURE_1u5l| PDB=1u5l | SCENE= }}
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'''Solution Structure of the turtle prion protein fragment (121-226)'''
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===Solution Structure of the turtle prion protein fragment (121-226)===
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==Overview==
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The NMR structures of the recombinant prion proteins from chicken (Gallus gallus; chPrP), the red-eared slider turtle (Trachemys scripta; tPrP), and the African clawed frog (Xenopus laevis; xlPrP) are presented. The amino acid sequences of these prion proteins show approximately 30% identity with mammalian prion proteins. All three species form the same molecular architecture as mammalian PrPC, with a long, flexibly disordered tail attached to the N-terminal end of a globular domain. The globular domain in chPrP and tPrP contains three alpha-helices, one short 3(10)-helix, and a short antiparallel beta-sheet. In xlPrP, the globular domain includes three alpha-helices and a somewhat longer beta-sheet than in the other species. The spatial arrangement of these regular secondary structures coincides closely with that of the globular domain in mammalian prion proteins. Based on the low sequence identity to mammalian PrPs, comparison of chPrP, tPrP, and xlPrP with mammalian PrPC structures is used to identify a set of essential amino acid positions for the preservation of the same PrPC fold in birds, reptiles, amphibians, and mammals. There are additional conserved residues without apparent structural roles, which are of interest for the ongoing search for physiological functions of PrPC in healthy organisms.
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The line below this paragraph, {{ABSTRACT_PUBMED_15647366}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15647366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15647366}}
==About this Structure==
==About this Structure==
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1U5L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trachemys_scripta Trachemys scripta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5L OCA].
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1U5L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trachemys_scripta Trachemys scripta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5L OCA].
==Reference==
==Reference==
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[[Category: Prp]]
[[Category: Prp]]
[[Category: Tse]]
[[Category: Tse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:54:35 2008''

Revision as of 15:54, 28 July 2008

Image:1u5l.png

Template:STRUCTURE 1u5l

Solution Structure of the turtle prion protein fragment (121-226)

Template:ABSTRACT PUBMED 15647366

About this Structure

1U5L is a Single protein structure of sequence from Trachemys scripta. Full experimental information is available from OCA.

Reference

Prion protein NMR structures of chickens, turtles, and frogs., Calzolai L, Lysek DA, Perez DR, Guntert P, Wuthrich K, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):651-5. Epub 2005 Jan 12. PMID:15647366

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