2trm

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{{STRUCTURE_2trm| PDB=2trm | SCENE= }}
{{STRUCTURE_2trm| PDB=2trm | SCENE= }}
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'''THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS'''
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===THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS===
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==Overview==
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The structure of the Asn102 mutant of trypsin was determined in order to distinguish whether the reduced activity of the mutant at neutral pH results from an altered active site conformation or from an inability to stabilize a positive charge on the active site histidine. The active site structure of the Asn102 mutant of trypsin is identical to the native enzyme with respect to the specificity pocket, the oxyanion hole, and the orientation of the nucleophilic serine. The observed decrease in rate results from the loss of nucleophilicity of the active site serine. This decreased nucleophilicity may result from stabilization of a His57 tautomer that is unable to accept the serine hydroxyl proton.
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The line below this paragraph, {{ABSTRACT_PUBMED_3112942}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 3112942 is the PubMed ID number.
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{{ABSTRACT_PUBMED_3112942}}
==About this Structure==
==About this Structure==
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[[Category: Finer-Moore, J.]]
[[Category: Finer-Moore, J.]]
[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:26:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:58:06 2008''

Revision as of 15:58, 28 July 2008

Image:2trm.png

Template:STRUCTURE 2trm

THE THREE-DIMENSIONAL STRUCTURE OF ASN102 MUTANT OF TRYPSIN. ROLE OF ASP102 IN SERINE PROTEASE CATALYSIS

Template:ABSTRACT PUBMED 3112942

About this Structure

2TRM is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis., Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS, Science. 1987 Aug 21;237(4817):905-9. PMID:3112942

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