2or7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2or7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2or7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2or7| PDB=2or7 | SCENE= }}
{{STRUCTURE_2or7| PDB=2or7 | SCENE= }}
-
'''Tim-2'''
+
===Tim-2===
-
==Overview==
+
<!--
-
The T cell immunoglobulin mucin (TIM) receptors are involved in the regulation of immune responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of the murine mTIM-1 and mTIM-2 receptors revealed an immunoglobulin (Ig) fold, with four Cys residues bridging a distinctive CC' loop to the GFC beta-sheet. The structures showed two ligand-recognition modes in the TIM family. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding. Biochemical, mutational, and cell adhesion analyses confirmed the divergent ligand-binding modes revealed by the structures. Structural features characteristic of mTIM-1 appear conserved in human TIM-1, which also mediated homophilic interactions. The extracellular mucin domain enhanced binding through the Ig domain, modulating TIM receptor functions. These results explain the divergent immune functions described for the murine receptors and the role of TIM-1 as a cell adhesion receptor in renal regeneration and cancer.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17363299}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17363299 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17363299}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Tim]]
[[Category: Tim]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:30:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:01:09 2008''

Revision as of 16:01, 28 July 2008

Image:2or7.png

Template:STRUCTURE 2or7

Tim-2

Template:ABSTRACT PUBMED 17363299

About this Structure

2OR7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family., Santiago C, Ballesteros A, Tami C, Martinez-Munoz L, Kaplan GG, Casasnovas JM, Immunity. 2007 Mar;26(3):299-310. PMID:17363299

Page seeded by OCA on Mon Jul 28 19:01:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2or7"
Personal tools